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however, these results should not be extrapolated to other p-gp inhibitors as colchicine is known to be a substrate for p-gp and case reports of colchicine toxicity associated with the co-administration of pgp inhibitors such as cyclosporine have been published.

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the evidence for the efficacy of colchicine in patients with chronic gout is derived from the published literature.

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in patients on probenecid and colchicine the use of salicylates in either small or large doses is contraindicated because it antagonizes the uricosuric action of probenecid.

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