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How much colchicine is too much

Posted by harmony on 5/10/2018


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review systemic toxicity associated with the intravenous administration of colchicine – guidelines for use.

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indeed, we recorded an increased i ca in colchicine-treated ventricular myocytes even just after rupture of the patch see figure 7 in reference 18 18 that argues against the dialysis dependence of microtubule-disruption effects.

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in some subjects with mild to moderate cirrhosis, the clearance of colchicine is significantly reduced and plasma half-life prolonged compared to healthy subjects.


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